Control Interpolation of Specific Clips Not Whole Video

I am creating a Kickstarter Trailer. The trailer includes footage of my game, which is Pixel Art, and then also video footage of me talking about the game. In order to make sure the pixels are crisp and square, I have to make the Interpolation set to Nearest Neighbor. But this causes the video footage of me talking to look worse. Is there a way to control interpolation for individual clips and not the whole video?

Doubt it. I think the better way would be process the clips separately then bring them all into a new project?

Well it all has to be one video, and it voices over video footage of the game and then switches back to us talking and then back to the game with the voiceover a lot, so that might not be possible, or worth it