I didn’t find any advantage when I was using it but that’s not to say there isn’t one, I use lots of effects in my work and it seemed to trip up most often when I had layers of effects on the same item. Say size&position, transparency, crop and chroma-key all on the same image or clip, and this was before key-frames were introduced. My feeling is that it may be because some of the combinations included effects that were GPU reliant with ones that weren’t, but that’s just speculation. Doing the same project without GPU effects would work OK.
Hudson’s suggestion re how to experiment sounds good to me. I had to completely recreate a project at one point when it wasn’t working out, and you want to avoid that if you can.